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Bachem H-Tyr-Lys-OH
Supplier: Bachem 4000819.0001
H-Tyr-Lys-OH, 54925-88-1, C15H23N3O4, Mr 309.37, 1g. Reaction of the dipeptide KY with diethylenetriaminepentaacetic (DTPA) cyclic anhydride yielded monovalent and bivalent haptens. In vitro, the antibody conjugate (which was prepared by coupling F(ab’)2 or Fab’ fragments of an antibody specific for the human high molecular weight melanoma associated antigen to Fab’ fragments of an antibody specific for In-DTPA complexes) mediated binding of the 111In-labeled haptens to melanoma cells. In vivo, it allowed specific localization of the haptens in A375 tumors. The bivalent hapten exhibited much higher efficiency at targeting 111In onto cells, both in vitro and in vivo.
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