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Enzo Life Sciences H-1152 . dihydrochloride, (1mg), CAS Number: 45146-2-58-1
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Supplier:  Enzo Life Sciences ALX270423M001

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ROCK inhibitor. A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632 (Prod. No. ALX-270-333). Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain. Alternative Name: H-1152P. 2HCl, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine . 2HCl. Formula: C16H21N3O2S . 2HCl. MW: 319.4 . 73.0. CAS Number: 45146-2-58-1. Purity: ≥98% (TLC). Appearance: White to off-white solid. Solubility: Soluble in water. Long Term Storage: -20°C

Catalog No. NC9527631


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