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Apexbio Technology LLC HA14-1 65673-63-4 20mg
Supplier: Apexbio Technology LLC A816820
HA14-1 (CAS 65673-63-4) is a small molecule inhibitor of B-cell lymphoma 2 (Bcl-2) protein By binding to the BH3 domain of Bcl-2 HA14-1 antagonizes its anti-apoptotic function thereby promoting the activation of pro-apoptotic proteins such as Bax In NIH3T3 HL60 and H1299 cell lines HA14-1 induces apoptosis with reported IC50 values ranging from 10 to 20 M Additionally it has been shown to inhibit ceramide glucosyltransferase HA14-1 is widely utilized as a chemical tool to investigate Bcl-2-mediated apoptotic pathways and is of interest in cancer research exploring targeted induction of cell death
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