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Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 1 ML
Supplier: Medchemexpress LLC HYN1584A10MM/1ML
Halofuginone hydrobromide (RU-19110 hydrobromide), a Febrifugine derivative, acts as a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and reduces osteoarthritis (OA) by inhibiting TGF-β activity. Additionally, it functions as a potent pulmonary vasodilator through the activation of Kv channels and the blocking of voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Inhibits type-I collagen synthesis
- Reduces osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator through Kv channel activation
- Blocks voltage-gated, receptor-operated, and store-operated Ca2+ channels
- Exhibits anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
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