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Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 50 MG
Supplier: Medchemexpress LLC HYN1584A50MG
Halofuginone hydrobromide (RU-19110) is a Febrifugine derivative that acts as a competitive prolyl-tRNA synthetase inhibitor. It is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. This compound exhibits various biological effects, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrosis activities. It also functions as a potent pulmonary vasodilator.
- Competitive prolyl-tRNA synthetase inhibitor.
- Inhibits type-I collagen synthesis.
- Attenuates osteoarthritis by inhibiting TGF-β activity.
- Potent pulmonary vasodilator, activating Kv channels and blocking Ca2+ channels.
- Exhibits anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
- Decreases NRF2 protein levels in tumors.
- Partially reverses established pulmonary hypertension.
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