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Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 500 MG
Supplier: Medchemexpress LLC HYN1584A500MG
Halofuginone hydrobromide is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. It also acts as a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM).
- Specific inhibitor of type-I collagen synthesis.
- Attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
- Potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Has anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
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