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ABclonal Technology Haptoglobin (HP) Rabbit pAb
Supplier: ABclonal Technology A15711000UL
This gene encodes a preproprotein that is processed into alpha and beta chains, which combine to form haptoglobin. Haptoglobin binds free plasma hemoglobin, preventing iron loss through the kidneys and protecting them from hemoglobin-induced damage. Mutations in this gene or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. The gene has been linked to diabetic nephropathy, coronary artery disease in type 1 diabetes, Crohns disease, inflammatory disease behavior, primary sclerosing cholangitis, Parkinsons disease susceptibility, and reduced incidence of malaria. The protein also has antimicrobial activity against bacteria. A duplicated gene similar to this one is located nearby on chromosome 16. Multiple transcript variants encoding different isoforms have been identified.
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