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Apexbio Technology LLC HATU 148893-10-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A70225.1
HATU (1-[Bis(dimethylamino)methylene]-1H-1 2 3-triazolo[4 5-b]pyridinium 3-oxid hexafluorophosphate) is a peptide coupling reagent routinely employed for amide-bond formation in peptide synthesis and other biomolecular applications In solution HATU converts carboxylic acids into active ester intermediates (OAt esters) facilitating subsequent nucleophilic attack from amines or alcohols This reaction typically proceeds in presence of basic additives such as N N-Diisopropylethylamine (DIPEA) under anhydrous conditions in solvents like dimethylformamide (DMF) Its utility extends to synthesizing peptides and modifying biomolecules through ester or amide linkage formation widely applied in biomedical research and pharmaceutical laboratories
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