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Genscript Corporation Antibody Protein Proteins Proteins 25 UG 1/EA
Supplier: Genscript Corporation Z0314225
Proheparin-binding EGF-like growth factor (HB-EGF) also known as DTR DTS and HEGFL is a member of the EGF family of mitogens. It is expressed in macrophages monocytes endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells epithelial cells and keratinocytes. Compared to EGF HB-EGF binds to the EGF receptor with a higher affinity and has been shown to bemore mitogenic likely due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has also been reported to act as a diphtheria toxin receptor mediating endocytosis of the bound toxin. Heparin-binding EGF-like growth factor has been shown to interact with NRD1 Zinc finger and BTB domain-containing protein 16 and BAG1.
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