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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z029431
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis organ hyperplasia and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
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