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Apexbio Technology LLC HC-030031 349085-38-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21005.1
HC-030031 (CAS 349085-38-7) is a selective antagonist targeting transient receptor potential ankyrin 1 (TRPA1) a member of the TRP ion channel family involved in chemical and mechanical sensory transduction In FLIPR calcium influx assays HC-030031 inhibited cinnamaldehyde- and allyl isothiocyanate (AITC)-induced TRPA1 activation with IC50 values of 4 9 M and 7 5 M respectively It showed negligible activity against TRPV1 TRPV3 and TRPV4 isoforms In rat models HC-030031 reduced AITC-induced nociceptive responses CFA-induced mechanical hypersensitivity and neuropathic sensitivity from spinal nerve ligation HC-030031 serves as a pharmacological tool to study TRPA1 functions particularly in pain research
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