STEMCELL Technologies Purmorphamine, Size: 10 mg

Supplier:  STEMCELL Technologies 1001049

Activate the Hedgehog pathway with Purmorphamine (Sinha and Chen. Nat Chem Biol, 2006). This tri-substituted purine derivative activates the Hedgehog pathway by directly binding to and activating the Hedgehog receptor Smoothened (Sinha and Chen. Nat Chem Biol, 2006). It promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Beloti et al. Cell Biol Int, 2005; Wu et al. J Am Chem Soc, 2002; Wu et al. Chem Biol, 2004), promotes differentiation of ventral spinal progenitors and motor neurons from human pluripotent stem cells (Hu and Zhang. Nat Protoc, 2009; Karumbayaram et al. Stem Cells, 2009; Li et al. Stem Cells, 2008), and inhibits differentiation and maturation of adipocytes from human mesenchymal cells (Fontaine et al. Stem Cells, 2008). Purmorphamine is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 520.6 g/mol; CAS number 483367-10-8. Visit STEMCELL.com for more information and related products.

Catalog No. NC2188014