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Eurofins Discoverx InCELL Hunter HEK 293 PI3Kδ Kinase Binding Cell Line, 2 vials. (96-0061C1)
Supplier: Eurofins Discoverx 960061C1
The InCELL Hunter HEK 293 PI3Kδ Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of PI3Kδ via detection of PI3Kδ levels. This product uses EFC technology. The cell line included overexpresses PI3Kδ target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
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