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Genscript Corporation HEK293/CLDN18.2 Stable Cell Li
Supplier: Genscript Corporation M00917
Claudins are a family of proteins which play a role in maintaining tight cell junctions Differentclaudin subtypes are expressed on different tissues Claudin18 isoform 2 (CLDN18 2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However CLDN 18 2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101) It has also beenshown to be expressed in a number of other cancers including pancreatic (50%) esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma asevidenced by effortsto target CLDN18 2 via naked antibody and CAR-T modalities
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