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Enzo Life Sciences Hellebrin (5mg). CAS: 13289-18-4
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Supplier:  Enzo Life Sciences ALX350105M005

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Cardiotonic glycoside which presents a bufadienolide-steroid structure. Besides ouabain (ALX-350-066), from the class of cardenolides hellebrin is the second unique water soluble cardiotonic glycoside. Extremely potent inhibitor of Na+/K+-ATPase (sodium pump) blocking the active efflux of Na+ and reuptake of K+ of this membrane enzyme. Shows a positive inotropic effect by increasing the intracellular Ca2+ concentration. Strong immunosuppressor inhibiting T cell activity with much higher potency than cortisol or cyclosporin A (BML-A195). Induces caspase-dependent apoptosis. Alternative name: 3beta-(O4-beta-D-glucopyranosyl-alpha-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5beta,14-beta-bufa-20,22-dienolide. Purity: ≥99% (HPLC). Appearance: White to off-white solid. Solubility: Soluble in water (4.4mg/ml). Long Term Storage: -20°C.

Catalog No. 50-200-8734


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