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Apexbio Technology LLC Hemin chloride(Synonyms: Hemin, Ferriprotoporphyrin IX chloride, Protohemin, Ferriheme chloride), 10g, CAS: 16009-13-5.
Supplier: Apexbio Technology LLC C398410000
Hemin chloride (CAS 16009-13-5) is an oxidized derivative of heme known to inhibit eukaryotic translation initiation factor 2 kinase 1 (eIF2 K1) a negative regulator of eIF-2 EIF2 phosphorylation at Ser51 generally transforms eIF2 into an inhibitor of its guanine-nucleotide exchange factor eIF2 In biochemical assays Hemin chloride (20 40 M) reduces phosphorylation of eIF-2 and eIF-2 enhancing translation activity in cellular lysates Animal studies show hemin administration induces heme oxygenase-1 (HO-1) expression and delays thrombus formation in mice demonstrating its usefulness in translational regulation and vascular biology research
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