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Gibco™ HepaRG™ Cells, Cryopreserved
Description
The HepaRG™ cell line is an immortalized hepatic cell line that retains many characteristics of primary human hepatocytes. HepaRG™ cells are terminally differentiated and provided in a convenient cryopreserved format. For scientists who need reproducible metabolism data, HepaRG™ cells are an in vitro tool that provides reproducible results in a metabolically complete and scalable system.
Obtain biologically relevant results from a metabolically complete system
Assess the drug-drug interaction potential of your compound
Experience reproducible results from a single population of cells
Biologically Relevant
HepaRG™ cells exhibit many characteristics of primary human hepatocytes including morphology, expression of key metabolic enzymes, expression of nuclear receptors, and drug transporters. Unlike HepG2 and Fa2N-4 cells, HepaRG™ cells have high P450 activity and complete expression of all nuclear receptors.
Predict Metabolism-based Drug-drug Interaction
HepaRG™ cells respond to prototypical P450 inducers and inhibitors to the same extent as primary hepatocytes, allowing HepaRG™ cells to be used to evaluate potential drug-drug interactions.
Infinitely Reproducible
HepaRG™ cells exhibit many characteristics of primary human hepatocytes and are essentially a single donor. These features allow users to obtain physiological relevant results for metabolism-based drug-drug interactions without the concern of donor variability and limited lot sizes that come with relying on donor tissue. (Note: The cells we provide are terminally differentiated).
HepaRG™ is a trademark of BioPredic International.
Biologically Relevant
HepaRG™ cells exhibit many characteristics of primary human hepatocytes including morphology, expression of key metabolic enzymes, expression of nuclear receptors, and drug transporters. Unlike HepG2 and Fa2N-4 cells, HepaRG™ cells have high P450 activity and complete expression of all nuclear receptors.
Predict Metabolism-based Drug-drug Interaction
HepaRG™ cells respond to prototypical P450 inducers and inhibitors to the same extent as primary hepatocytes, allowing HepaRG™ cells to be used to evaluate potential drug-drug interactions.
Infinitely Reproducible
HepaRG™ cells exhibit many characteristics of primary human hepatocytes and are essentially a single donor. These features allow users to obtain physiological relevant results for metabolism-based drug-drug interactions without the concern of donor variability and limited lot sizes that come with relying on donor tissue. (Note: The cells we provide are terminally differentiated).
HepaRG™ is a trademark of BioPredic International.
Specifications
Specifications
| Content And Storage | 1 vial, store in cryostorage dewar or -135°C freezer |
| Age | Adult |
| Cell Line | HepaRG |
| Cell Type | Hepatocytes |
| Form | Cryopreserved |
| Gender | Female |
| Species | Human |
| Donor Source | Single Donor |
| No. of Cells | 10 x 106 |
| Product Type | Hepatocytes |
| Show More |
For Research Use Only. Not for use in diagnostic procedures.
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