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Sigma Aldrich Fine Chemicals Biosciences HepaRGTM Cells AHR one
Supplier: Sigma Aldrich Fine Chemicals Biosciences MTOX10131VL
HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG AHR knockout cells express the major xenobiotic sensors (PXR and CAR) drug transporters phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.
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