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Medchemexpress LLC Heptamidine dimethanesulfonate | 161374-55-6 | 99.8% | 560.68 | 100 MG
Supplier: Medchemexpress LLC HY16918A100MG
Heptamidine dimethanesulfonate, also known as SBi4211 dimethanesulfonate, is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM. It selectively eliminates melanoma cells that express S100B, while sparing those without it. This compound also serves as a valuable tool for myotonic dystrophy (DM) research, demonstrating the ability to rescue mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC50 value of 15 μM and reversing splicing defects and myotonia in a DM mouse model. The product has a purity of 99.82%, a CAS number of 161374-55-6, and a molecular weight of 560.68.
- Potent S100B inhibitor
- Selective melanoma cell elimination (S100B-positive)
- Useful tool for myotonic dystrophy (DM) investigation
- Reverses splicing defects and myotonia in DM models
- High purity: 99.82%
- Molecular weight: 560.68
- Off-white to light yellow solid
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