ABclonal Technology HER2/ErbB2 Rabbit mAb

Supplier:  ABclonal Technology A21248100UL

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases This protein has no ligand binding domain of its own and therefore cannot bind growth factors However it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported with the most common allele Ile654 Ile655 shown here Amplification and or overexpression of this gene has been reported in numerous cancers including breast and ovarian tumors Alternative splicing results in several additional transcript variants some encoding different isoforms and others that have not been fully characterized

Catalog No. 50-000-05670