AdipoGen HES1 human rec His

Supplier:  AdipoGen AG40A0180C050

Protein. Human HES1 aa 2-280 is fused at the N-terminus to a His-tag. Source E. coli. Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Purity >90% SDS-PAGE. bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 Hairy and Enhancer of Split 1 is a basic Helix-Loop-Helix bHLH transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia ALL, where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL B-ALL leads to growth arrest and apoptosis.

Catalog No. 50-256-2956