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Medchemexpress LLC Higenamine hydrochloride | 11041-94-4 | 307.77 | 500 MG
Supplier: Medchemexpress LLC HYN2037A500MG
Higenamine hydrochloride is a selective inhibitor of LSD1 with an IC50 of 1.47 μM, naturally sourced from aconite. It exhibits anti-inflammatory and antibacterial properties and can mitigate IL-1β-induced apoptosis via the ROS-mediated PI3K/Akt signaling pathway. Additionally, it offers protective effects for brain cells against oxygen deprivation and stimulates bone formation in osteoporosis through the SMAD2/3 pathway. It is utilized in research for various conditions, including cancer, inflammation, and cardiorenal syndrome.
- Selective LSD1 inhibitor (IC50=1.47 μM)
- Derived from aconite
- Possesses anti-inflammatory activity
- Exhibits antibacterial activity
- Attenuates IL-1β-induced apoptosis
- Protects brain cells from oxygen deprivation
- Promotes bone formation in osteoporosis
- Relevant for studying cancer, inflammation, and cardiorenal syndrome
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