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Cayman Chemical HInokIflavon 10mg
Supplier: Cayman Chemical 3633810 MG
A biflavonoid with diverse biological activities; inhibits the aggregation of Aβ40 in vitro (IC50 = 9.5 μM); promotes pre-mRNA splicing of the genes encoding Mcl-1 and eIF4α and inhibits pre-mRNA splicing of the genes encoding Hsp40 and RIOK3 in NB4 cells at 10 µM; increases protein SUMOylation in HEK293 cells at 10 µM; reduces the cytopathic effect of the influenza A subtypes H1N1 and H1N3, influenza B, parainfluenza type 3, and RSV (IC50s = 1.4, 1.3, 1.2, 1, and 2.5 UG/ml, respectively); inhibits the migration and invasion of, and induces apoptosis in, KYSE-150 cells from 10-40 µM; reduces tumor volume in a KYSE-150 mouse xenograft model at 25 or 50 mg/kg
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