Invitrogen™ Human HIPK2, GST Tag Recombinant Protein

Catalog No.	Quantity
PV5276	1 mg
PV5275	10 μg
PR9004A	100 μg

Catalog No. PV5276 Supplier Invitrogen™ Supplier No. PV5276

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic

The HIPK2 gene encodes a member of the homeodomain-interacting protein kinase family, specifically a serine/threonine nuclear protein kinase. HIPK2 plays versatile roles in cellular processes, including transcription regulation, cell proliferation, differentiation, and apoptosis. It interacts with various transcription factors and proteins, contributing significantly to the modulation of gene expression. Notably, HIPK2 is involved in the activation of the tumor suppressor protein p53, with p53-dependent pro-apoptotic activity, positioning HIPK2 as a potential tumor suppressor gene. Recent studies highlight its downregulation in multiple tumor types and its emerging role in cancer biology and therapy. Its expression is subject to quality control mechanisms, including autophosphorylation at serine and threonine sites. Structurally, the crystal structure of HIPK2 reveals unique conformational attributes that contribute to its functionality in different signaling pathways. HIPK2's influence extends to physiological processes, such as fibrosis and central nervous system regulation, indicating its broad biological significance and potential therapeutic applications.

Specifications

• Accession Number: Q9H2X6
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with no preservative
• Gene ID (Entrez): 28996
• Molecular Weight (g/mol): 73 kDa
• Name: Human HIPK2, GST Tag
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12
• Common Name: HIPK2
• Gene Symbol: HIPK2
• Kinase Family: DYRK Kinase Family
• Protein Length: 165-564
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 165-564
• Content And Storage: Kinase proteins are shipped on dry ice and should be stored at -80°C.
• Kinase Group: Ser⁄Thr Kinases: CMGC Group
• Shipping Condition: Dry Ice
• Expression System: Baculovirus
• Protein Family: Kinases & Inhibitors
• Protein Form: Catalytic
• Form: Liquid
• Research Category: Drug Development