Invitrogen™ Human HIPK3 (YAK1), His Tag Recombinant Protein

Catalog No.	Quantity
PV4209	10 μg

Catalog No. PV4209 Supplier Invitrogen™ Supplier No. PV4209

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

HIPK3 is a serine/threonine kinase involved in signal transduction, cellular communication, and multidrug resistance of tumors and plays a role in the phosphorylation of FADD. HIPK3 negatively regulates apoptosis by promoting FADD phosphorylation. This kinase enhances androgen receptor-mediated transcription, and may act as a transcriptional corepressor for NK homeodomain transcription factors.

Specifications

• Accession Number: Q9H422
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 150mM NaCl, 0.02% Triton X-100, 50% glycerol, 2mM DTT, 0.5mM EDTA and no preservative; pH 7.5
• Gene ID (Entrez): 10114
• Molecular Weight (g/mol): 49.7 kDa
• Name: Human HIPK3 (YAK1), His Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: Androgen receptor-interacting nuclear protein kinase; ANPK; DYRK6; Fas-interacting serine/threonine-protein kinase; FIST; FIST3; HCMV-interacting protein; HIPK3; homeodomain interacting protein kinase 3; homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; mir-1902; nbak3; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; PKY; RP1-8L15.1; YAK1
• Common Name: HIPK3
• Gene Symbol: HIPK3
• Kinase Family: DYRK Kinase Family
• Protein Length: aa 163-562
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: 163-562
• Content And Storage: Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% Glycerol
  Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
• Assay Entry: Biochemical binding/kinetic
• Kinase Group: Ser⁄Thr Kinases: CMGC Group
• Shipping Condition: Dry Ice
• Target Entry: HIPK3
• Target Gene: homeodomain interacting protein kinase 3
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Catalytic
• Form: Liquid
• Protein Subtype: Serine/Threonine Kinases
• Research Category: Drug Discovery: Signal Transduction
• Purity or Quality Grade: 85% by SDS-PAGE