CPC Scientific Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt (acetate salt) 5MG

Supplier:  CPC Scientific LHRH014A

As a potent LHRH agonist, histrelin stimulates LH and FSH release and inhibits the actions of sex steroids on the male and female reproductive tracts. Its potency in vivo and in vitro is similar to that of the D-Trp6-containing analog. Especially because of its high water solubility and greater lipophilic character, histrelin appears promising for clinical application.Slow-release implants containing histreline implants were approved for the palliative treatment of advanced hormone-dependent prostate cancer.ONE-LETTER SEQUENCE: Pyr-HWSYh(Bzl)-LRP-NHEtMOLECULAR FORMULA: C66H86N18O12MOLECULAR WEIGHT:1323.52STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [220810-26-4], RESEARCH AREA: HormonalREFERENCES: K.Sundaram et al., Life Sci., 28, 83 (1981); J.DeFazio et al., Endocr. Res., 10, 163 (1984); M.J.Gibson and D.S.Kohtz, Contraception, 31, 91 (1985); M.J.Karten and J.E.Rivier, Endocr. Rev., 7, 44 (1986); G.C.Doelle et al., Horm. Metab. Res., 18, 201 (1986); J.W.Gunnet et al., J.

Catalog No. 50-210-9663