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Cayman Chemical HIV-1 Integrase InhIbItr 25mg

Supplier: Cayman Chemical 3877925 MG
An inhibitor of HIV-1 integrase strand transfer (IC50s = 0.07 and 0.33 µM in the presence of manganese and magnesium, respectively); selective for strand transfer over 3ʹ DNA processing (IC50 = >70 µM in the presence of either manganese or magnesium); selective for wild-type HIV-1 integrase over HIV-1 integraseF185K/C280S (IC50 = 1.53 µM in the presence of manganese); reduces the secreted levels of p24 in CEM-SS and H9 cells (IC50s = 11 and 7 µM, respectively) without inducing cytotoxicity (CC50s = 600 and 400 µM, respectively)
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