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Cayman Chemical HJC0152hydrochlorIde 10mg
Supplier: Cayman Chemical 2235110 MG
An orally bioavailable inhibitor of STAT3 (32 and 62% inhibition at 10 and 20 µM, respectively, in MDA-MB-231 cells in a luciferase reporter assay); inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer and AsPC-1 and PANC-1 pancreatic cancer cells (IC50s = 0.91, 1.64, 1.9, and 1.08 µM, respectively); inhibits tumor growth in a breast cancer mouse xenograft model at doses of 7.5 mg/kg, i.p. or 25 mg/kg, p.o.; inhibits tumor growth in an orthotopic mouse model of squamous cell carcinoma
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