Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC HKI-357 | 848133-17-5 | MFCD26792555 | 99.2% | 574.05 g/mol | C31H29ClFN5O3 | 100 MG
Supplier: Medchemexpress LLC HY103443100MG
HKI-357 is a small-molecule, irreversible dual inhibitor of EGFR and ERBB2 with low-nanomolar potency. It inhibits EGFR (IC50 34 nM) and ERBB2 (IC50 33 nM), suppresses EGFR autophosphorylation at Y1068, and reduces AKT and MAPK phosphorylation. HKI-357 is used in biochemical assays and cell-based studies to probe EGFR/ERBB2 signaling and evaluate inhibitor activity in preclinical cancer research.
- Irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM.
- Suppresses EGFR autophosphorylation (Y1068) and downstream AKT and MAPK phosphorylation.
- High purity (99.2% by HPLC) suitable for research applications.
- Available in milligram quantities for dose-ranging and assay setup.
- Suited for biochemical kinase assays and cell signaling studies.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?