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STEMCELL Technologies Anti-Human HLA-DR Antibody, Clone LN3, Size: 100 ug
Supplier: STEMCELL Technologies 60164
The LN3 antibody reacts with the HLA-DR antigen a major histocompatibility complex (MHC) class II receptor encoded within the human leukocyte antigen (HLA) complex on chromosome 6. HLA-DR is a heterodimeric transmembrane glycoprotein comprising non-covalently associated alpha (36 kDa) and beta (27 kDa) subunits. MHC class II plays a central role in the presentation of antigen-derived peptides to CD4 T cells along with CD3/TCR and CD4. HLA-DR is primarily expressed on the surface of antigen-presenting cells including B cells dendritic cells monocytes macrophages thymic epithelial cells and activated T and natural (NK) cells. The LN3 antibody binds to an extracellular epitope that reportedly resides within the HLA-BR1 subunit of HLA-DR.
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