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Apexbio Technology LLC HLCL-61 1158279-20-9 10mg
Supplier: Apexbio Technology LLC B780610
HLCL-61 (CAS 1158279-20-9) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in the epigenetic regulation of gene expression through symmetric dimethylation of arginine residues on histones and other proteins HLCL-61 shows specificity for PRMT5 exhibiting no inhibitory activity against PRMT1 PRMT4 or other type II PRMT family members In cellular studies HLCL-61 suppresses symmetric dimethylation of histones H3 and H4 leading to reduced viability and enhanced differentiation of acute myeloid leukemia (AML) cell lines and primary blasts HLCL-61 is currently utilized in preclinical research to investigate PRMT5-mediated epigenetic mechanisms in cancer
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