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Cayman Chemical HLCL-61hydrochlorIde 10mg
SDP

Supplier:  Cayman Chemical 1989710 MG

Encompass_Preferred

A PRMT5 inhibitor; inhibits the growth of multiple AML cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively); selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay; induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner; increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter

Catalog No. 50-298-4599


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