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Selleck Chemical LLC HLM006474-5mg
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Supplier:  Selleck Chemical LLC S89635MG

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HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 µM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.

Catalog No. 50-238-9706


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