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AdipoGen anti-HMGB1, mAb (rec.) (Giby-1-4) (100 µg)
Supplier: AdipoGen AG27B0002C100
Recombinant Antibody. Recognizes human, mouse and rat HMGB1. Species cross-reactivity: Human, Mouse, Rat. Clone: Giby-1-4. Isotype: Human IgG2lambda. Applications: ELISA, WB. Host: Purified from HEK 293 cell culture supernatant. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. HMGB1 is a causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis. Anti-HMGB1, mAb (recombinant) (Giby-1-4) (Biotin) is an antibody developed by antibody phage display technology using a human naive antibody gene library.
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