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Medchemexpress LLC HMN-176 | 173529-10-7 | MFCD00945108 | 99.4% | 382.43 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY13647100MG

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HMN-176 is a stilbene derivative that inhibits mitosis by interfering with polo-like kinase-1 (PLK1), without significantly affecting tubulin polymerization. It is intended for research use only and is not sold to patients.

  • Inhibits mitosis by interfering with polo-like kinase-1 (PLK1).
  • Does not significantly affect tubulin polymerization.
  • Increases mitosis duration in hTERT-RPE1 and CFPAC-1 cell lines (at 2.5 μM).
  • Inhibits aster formation in a concentration-dependent manner.
  • Demonstrates inhibitory effects in multiple tumors (breast, non-small-cell lung, ovarian).
  • Shows potent cytotoxicity (mean IC50 of 118 nM).
  • Suppresses MDR1 mRNA expression by 56% (at 3 μM).

Catalog No. 50-003-52052


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