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Innovative Research Inc Hmn tPA Pur Non-Enzy/Cleav 1mg
Supplier: Innovative Research Inc IHUTPANENC1MG
Human tPA Purified Non-Enzymatic Non-Cleavable 1mg - Human tPA Purified Non-Enzymatic Non-Cleavable from Innovative Research is recombinantly produced in insect cells and purified using affinity chromatography. This is a frozen liquid buffered in 0.4M HEPES; 0.1M NaCl; pH 7.4 and a purity of >95%. This product is useful as a positive control for ELISA and western blot as well as cell differentiation, cell signaling, clotting assays, fibrinolysis, plasminogen activation, protein-protein interactions, receptor binding, thromboelastography, and thrombolysis. Human tPA with a double mutation that is permanently single chain and lacks catalytic activity. The non-catalytic mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB locus TPA_HUMAN, accession P00750). The non-cleavable mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB locus TPA_HUMAN, accession P00750).
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