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Apexbio Technology LLC HO-3867 1172133-28-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B49705.1
HO-3867 (CAS 1172133-28-6) is a synthetic curcumin analog that functions as a selective inhibitor of signal transducer and activator of transcription 3 (STAT3) By specifically blocking STAT3 phosphorylation transcriptional activity and DNA binding HO-3867 suppresses the expression of STAT3-mediated genes involved in cellular proliferation and survival without affecting other STAT family members In cell-based studies HO-3867 induces apoptosis in ovarian and endometrial cancer cells while exhibiting minimal cytotoxicity toward nonmalignant cells In vivo HO-3867 reduces tumor growth in xenograft mouse models and inhibits vascular smooth muscle cell proliferation by upregulating PTEN expression This compound is valuable for investigating STAT3-driven oncogenesis and related cellular pathways
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