Apexbio Technology LLC HOBt 2592-95-2 100g

Supplier:  Apexbio Technology LLC A7025100000

HOBt (1-Hydroxybenzotriazole) is an organic benzotriazole derivative extensively utilized in peptide chemistry Structurally it is characterized as a crystalline powder typically containing bound water molecules (approximately 11 7% by weight) Functionally HOBt serves as a racemization inhibitor during peptide coupling minimizing epimerization of stereocenters In peptide synthesis it participates in the generation of reactive ester intermediates such as N-hydroxysuccinimide esters These activated esters react under mild conditions with amino groups facilitating efficient amide bond formation Additionally HOBt enables preparation of amide analogues from carboxylic acids not readily convertible into acyl chlorides thus expanding synthesis options for antibiotic derivatives and related bioactive molecules

Catalog No. 50-000-61487