Homopiperazine, 98%

Description

CAS: 505-66-8 | C5H12N2 | 100.165 g/mol

Homopiperazine is used to prepare 1,4-bis-(2-thiazolyl)-1,4-diazacycloheptane by reacting with 2-bromo-thiazole. It acts as an intermediate for repaglinide and fasudil hydrochloride. It is also used in the preparation of potent H3 receptor antagonists, which is used for the treatment of neurodegenerative conditions. Further, it is used in vesicant, cosmetic, emulsifier and energetic material. It acts as a corrosion inhibitor for iron. In pharmaceuticals, it is employed as antipyretic and reducing blood sugar, adiposity, calm, antipsychotic and anti-nervous.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Homopiperazine is used to prepare 1,4-bis-(2-thiazolyl)-1,4-diazacycloheptane by reacting with 2-bromo-thiazole. It acts as an intermediate for repaglinide and fasudil hydrochloride. It is also used in the preparation of potent H3 receptor antagonists, which is used for the treatment of neurodegenerative conditions. Further, it is used in vesicant, cosmetic, emulsifier and energetic material. It acts as a corrosion inhibitor for iron. In pharmaceuticals, it is employed as antipyretic and reducing blood sugar, adiposity, calm, antipsychotic and anti-nervous.

Solubility
Soluble in water.

Notes
Hygroscopic. Air sensitive. Incompatible with strong oxidizing agents and strong acids.

Specifications

Chemical Identifiers

• CAS: 505-66-8
• Molecular Formula: C5H12N2
• Molecular Weight (g/mol): 100.165
• MDL Number: MFCD00006933
• InChI Key: FQUYSHZXSKYCSY-UHFFFAOYSA-N
• Synonym: homopiperazine, 1,4-diazacycloheptane, 1h-1,4-diazepine, hexahydro, hexahydro-1,4-diazepine, 1,4 diazepane, perhydro-1,4-diazepine, trimethyleneethylenediamine, 1,4-diazepan, unii-95cl167w8t, hexahydro-1h-1,4-diazepine
• PubChem CID: 68163
• IUPAC Name: 1,4-diazepane
• SMILES: C1CNCCNC1

• Melting Point: 38°C to 44°C
• Density: 0.95
• Boiling Point: 168°C to 170°C
• Flash Point: 64°C (147°F)
• Odor: Amine-like
• Quantity: 100 g
• UN Number: UN3259
• Beilstein: 102711
• Sensitivity: Air sensitive; Hygroscopic
• Solubility Information: Soluble in water.
• Formula Weight: 100.17
• Percent Purity: 98%
• Chemical Name or Material: Homopiperazine

Safety and Handling

Hazard Category	H312-H314
Hazard Statement	GHS H Statement H314-H318-H312 Causes severe skin burns and eye damage. Causes serious eye damage. Harmful in contact with skin.
Precautionary Statement	P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S.
EINECSNumber	208-016-1
RTECSNumber	HM3850000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only