AdipoGen HpARI CCP1 2 rec His

Supplier:  AdipoGen AG40B0201C050

Recombinant protein. Heligmosomoides polygyrus protein HpARI aa 17-165 is fused at the C-terminus to a His-tag. Binds to human and mouse IL-33. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. HpARI is a protein secreted by the mouse parasite Heligmosomoides polygyrus. The mature protein HpARI, containing three predicted Complement Control Protein CCP-like modules also known as Short Consensus Repeats SCRs or sushi-domains, suppresses type 2 allergic immune responses through interference in the interleukin-33 IL-33 pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. A non-natural truncation consisting of the first 2 domains of HpARI CCP1/2 retains IL-33 and DNA binding capacity. HpARI CCP1/2 is able to stabilize IL-33, increasing its half-life and amplifying its effects.

Catalog No. 50-256-2889