Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. HPI 1, Tocris Bioscience™

HPI 1, Tocris Bioscience™

Catalog No. 383950
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
38-395-0 50 mg
38-391-0 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 38-395-0 Supplier R&D Systems Supplier No. 3839/50
This item is not returnable. View return policy

Description

Inhibits Hedgehog signaling

Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.

Chemical Identifiers

CAS 599150-20-6
Molecular Formula C27H29NO6
Molecular Weight (g/mol) 463.53
InChI Key ZXSWZQSYZYMZKS-UHFFFAOYSA-N
Synonym hpi-1, hpi 1, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-4,6,7,8-tetrahydro-1h-quinoline-3-carboxylate, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphe nyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, 1,4,5,6,7,8-hexahydro-4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester, 2-methoxyethyl 4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-1,4,6,7, 8-pentahydroquinoline-3-carboxylate, 3-quinolinecarboxylic acid, 1,4,5,6,7,8-hexahydro-4-3-hydroxyphenyl-7-2-methoxyphenyl-2-methyl-5-oxo-, 2-methoxyethyl ester
PubChem CID 2926768
IUPAC Name 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
SMILES CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC

Specifications

Quantity 50 mg
Formula Weight 463.52
Percent Purity >95%
Chemical Name or Material HPI 1

Safety and Handling

Recommended Storage Store at -20°C
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.