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Medchemexpress LLC HPK1-IN-3 | 2739844-34-7 | 98.6% | 490.45 | 50 MG
SDP

Catalog No. 5000350628
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HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. It exhibits IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs).

  • Potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor
  • IC50 of 0.25 nM
  • Exhibits IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)
  • Treatment shows statistically significant elevation of proinflammatory cytokines IL-6 and TNF-α in a concentration-dependent manner in human monocyte-derived dendritic cells when treated with 0.25-4 μM for 24 hours

Catalog No. 50-003-50628 Supplier Medchemexpress LLC Supplier No. HY13856850MG
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HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. It exhibits IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs).

  • Potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor
  • IC50 of 0.25 nM
  • Exhibits IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)
  • Treatment shows statistically significant elevation of proinflammatory cytokines IL-6 and TNF-α in a concentration-dependent manner in human monocyte-derived dendritic cells when treated with 0.25-4 μM for 24 hours

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