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Medchemexpress LLC HPK1-IN-7 | 2320462-65-3 | 99.3% | 458.47 | 50 MG
Supplier: Medchemexpress LLC HY13874250MG
HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50 = 2.6 nM) with excellent family and kinome selectivity. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1.
- Potent, orally active HPK1 inhibitor (IC50 = 2.6 nM)
- Excellent family and kinome selectivity
- Shows selectivity against IRAK4 (59 nM) and GLK (140 nM)
- Robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1
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