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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA
Supplier: Genscript Corporation Z0305150
Heregulin1-Beta1(HRG1-Beta1) is one of the isoforms encoded by Neuregulin (NRG) genes. NRGs are synthesized as large transmembrane precursor proteins and the NRG family has 4 members and 26 isoforms. These isoforms provide large diversities including different tissue distribution variable potencies and different biological functions. HRG1-beta 1 belongs to Type I HRG1 and is expressed in neural tissue respiratory epithelia and heart. In vivo HRG1 binds and activates both ErbB3 and ErbB4 the transmembrane receptor tyrosine kinase and is involved in the proliferation differentiation and survival of cells. Aberrantly produced HRG1 could be used in the constitute activation of the ErbB receptors; therefore the upregulation of HRG1 contributes to the development of tumors including breast cancer.
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