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Cayman Chemical HS MInral OIl asy Reagent 15mL
Supplier: Cayman Chemical 66091015 ML
A kainate receptor agonist induces currents in Xenopus oocytes expressing homomeric GluR5 or GluR2 subunit-containing receptors (EC50s 0.16 and 0.23 UM respectively) induces desensitization in HEK293 cells expressing homomeric GluR6 subunit-containing kainate receptors at 0.03-0.3 UM selectively binds to the kainate receptor (IC50 ~0.035 UM) over the AMPA and NMDA receptors (IC50s >100 and 7 UM respectively) but does bind to EAAT2 (Kb 3.4 UM) and inhibits glutamate transport reduces hind paw withdrawal frequency and increases withdrawal latency to mechanical and thermal stimuli in a rat model of capsaicin-induced hyperalgesia at 10 50 and 100 mg/kg
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