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Medchemexpress LLC HSDVHK-NH2 | 848644-86-0 | 99.5% | 720.78 | 10 MG
SDP

Supplier:  Medchemexpress LLC HYP118710MG

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HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction. It has an IC50 of 1.74 μg/mL (2.414 pM) and shows strong antagonism against αvβ3-GRGDSP interaction. This compound inhibits HUVEC proliferation by inducing cell death through caspases activations, which is linked to increased p53 expression.

  • Antagonist of integrin αvβ3-vitronectin interaction
  • Inhibits bFGF-induced cell migration
  • Shows strong antagonism against αvβ3-GRGDSP interaction
  • Inhibits HUVEC proliferation
  • Induces HUVEC cell death via caspases activations
  • Mechanism related to increased p53 expression

Catalog No. 50-004-22658


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