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Medchemexpress LLC Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] | 1268273-90-0 | 98.1% | 464.58 | C24H28N6O2S | 5MG
SDP

Supplier:  Medchemexpress LLC HY126225MG

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HSP70-IN-1 is a small-molecule heat shock protein 70 (HSP70) inhibitor for research use. It inhibits growth of Kasumi-1 cells (IC50 = 2.3 μM) and HSP70-dependent functions (IC50 ≈ 1.9 μM in MOLM13 caspase assays), disrupts Hsp70-HOP-Hsp90 complex formation, impairs refolding of heat-denatured luciferase, and induces apoptosis in cancer cells.

  • Inhibits HSP70 activity and HSP70-dependent cell growth.
  • Demonstrated cell potency with low micromolar IC50 values.
  • Interferes with chaperone complex formation and client protein stability.
  • Inhibits protein refolding in cellular assays.
  • Supplied as a high-purity research reagent (purity reported ~98.1%).
  • Available in multiple solid and solution pack sizes for assay flexibility.

Catalog No. 50-203-0046


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