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Invivogen CDS Agonist - LyoVec complexed, 100ug
SDP

Supplier:  Invivogen TLRLHSV60C

Encompass

HSV-60 is a 60 bp oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome [1].  Transfected HSV-60 potently induces an immune response following recognition by the cytosolic DNA sensors (CDSs),  DEAD-box protein 41 (DDX41) [2] or interferon γ-inducible protein 16  (IFI16) [1]. IFI16 induces innate immune responses against single-stranded (ss)and double-stranded (ds) intracellular DNA while DDX41 detects not only viral dsDNA but also bacterial cyclic dinucleotides. DDX41 and IFI16 activation trigger type I interferon (IFN) induction via the STING/TBK1 pathway. 

Catalog No. NC1348619


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