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FUJIFILM BIOSCIENCES INC ACF Human PDGF-BB, Recombinant Protein, Shenandoah Biotechnology, 10 ug vial
Supplier: FUJIFILM BIOSCIENCES INC 10018AF10UG
Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-A, TGF-B, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-A and PDGFR-B.
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