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ACROBiosystems Human Alpha-synuclein 2Vials
Supplier: ACROBiosystems CHEKATP0852VIALS
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinsons disease (PD). Alpha-synuclein is present in Lewy-bodies the neuropathological hallmark of PD and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
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